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As a postdoc in the US, is it possible to apply for funding for a project, which can be used to support one or two undergrad/MS/PhD students?

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The answer depends on the funding agency. Some agencies only require a PhD for the PI, in which case it's certainly possible, although it can be difficult to secure funding with only a postdoc as PI. (Many such proposals might have a more senior scientist as co-investigator.)

Other programs have specific requirements that the PI hold a more senior position, such as a tenure-track position, in which case a postdoc could not apply as the primary or sole or investigator.

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    Institutions also have varying rules about whether postdocs can apply for grants. Commented Apr 8, 2018 at 1:21

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