There are three widely-followed world university rankings: the THE, the QS, and the ARWU. You'll find discrepancies between them of course, but given they have different methodologies, it's not surprising. Make sure you know what you're looking for and what's important to you before using them. For example, the ARWU relies heavily on Nobel Laureates & Fields Medallists as staff or alumni. If you don't care about the natural sciences or mathematics, then these things are irrelevant, and the ARWU might be less applicable to you.
I am not as familiar with regional rankings, but my understanding is that the US News and World Report rankings is widely followed within the US, while in the UK, there are another three regional rankings (The Complete University Guide, The Guardian, and The Times/The Sunday Times). Once again they use different methodologies and so reach different results. To quote:
The considerable disparity in rankings has been attributed to the different methodology and purpose of global university rankings ... International university rankings primarily use criteria such as academic and employer surveys, the number of citations per faculty, the proportion of international staff and students and faculty and alumni prize winners ... The national rankings, on the other hand, give most weighting to the undergraduate student experience, taking account of teaching quality and learning resources, together with the quality of a university's intake, employment prospects, research quality and drop-out rates.
Hopefully you can see the difficulty in ranking universities, and why different people look at different rankings. You'll have to decide what is and isn't important to you.