I'm curious to hear whether there is general guidance on when and whether to submit a pre-submission inquiry to a high impact journal (field: biology). Our goal is to identify a journal that will send our paper out for review. I understand pre-submissions are best when there really is a question of appropriateness, e.g., you are submitting a software-oriented manuscript to an experimental biology journal.

I am less clear on whether the current situation will benefit from a pre-submission inquiry. Consulting with my PI, and other faculty on the floor, there seems to be wide disagreements about the utility of pre-submission. Some argue these inquiries are more efficient than full submissions, since formatting a paper for each journal is usually time intensive. Others say they've had pre-submissions meet strong approval, then get editorially rejected. Any general thoughts on this?