(Some) journals request that authors follow a specific style manual (e.g., APA or Chicago manuals of style). One style rule is to avoid starting a sentence with an abbreviation (with some exceptions). However, I found it unnecessary to spell out abbreviations like ANOVA (analysis of variance) or FMM (finite mixture models) every time I start sentences with them. Should I strictly follow such rules in academic writing? **Edit:** My field is biohealth sciences.