I'm a fairly new chemical engineering graduate student. I've been doing research for one semester so far (in molecular dynamics) and in the process have learned about journals and "impact factor" (a concept I didn't even know existed in my undergrad).
My advisor has told me that getting in Nature or Science is very difficult to do. I don't think anyone in the department has a paper in that journal. In fact, looking at the professors' research in my undergrad school (a top 5 engineering school), I don't see Nature papers either.
So after reading the journals themselves, I have to say that I'm kind of confused on what makes the articles published in them different than those published in something like JACS or ACS Nano. They seem more general in scope, and maybe some of them are "groundbreaking" in a sense, but the other articles, I just can't really tell...
What kind of research would I need to do in order to successfully submit a paper to one of these journals? I've got 4 years left and have some sway in what I would like to research, so I think this would be a good goal for grad school (even if I don't reach it).