Context: As PhD candidate, I'll have my first journal paper ready to submit around July 15th. My lab will be closed due to summer break for 5 weeks from July 23rd to August 29th. I will not work full-time during this break, and my supervisors/co-authors might not respond to their emails. Moreover, I won't be able to work (or maybe even to answer my emails) during the two last weeks of August, because of travel conditions.
Question: Would my potential lack of reactivity during this period depreciate my submission? In other words, should I submit my paper right before going on holidays, or should I wait until I return from vacations in order to be more reactive to reviewers comments?