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Does publishing in what is known as a "predatory" (such as OMICS) journal diminish ones reputation? Do these publications help at all when applying for grants (or do they impede ones chance)?

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Yes, your reputation is diminished, because people will think you couldn't get published any other way. It will actively harm your chances at pretty much any interaction with reputable organizations, including grant proposals. Don't do it.

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    (One of my pet peeves.) Publications can harm only passively. I guess you said actively to mean seriously / heavily / strongly; it's unlikely that any actions will be taken by the publication. Commented Jul 31, 2015 at 22:29
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    @PiotrMigdal: No, "actively" is the right word here. What jakebeal's sentence means is that publishing in a predatory journal will not merely fail to help one's chances, and not merely take effort away from things that will help one's chances; but rather, that it in itself will harm one's chances. This doesn't necessarily imply anything about the strength of the harm (except that it is enough to be worth mentioning). (If it makes you feel better, the "it" here refers to publishing, not publications. And publishing certainly is an action.)
    – ruakh
    Commented Aug 1, 2015 at 7:10

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