For many years on-line (a/k/a, "distance learning") degrees have been offered by regionally accredited universities In the USA. Until a decade or so ago, most of the degrees were earned by schools that specialized in distance learning. Even graduates of schools that had physical campuses and regional accreditation who studied full-time on campus were perceived as having earned their degrees through distance learning. Over the course of many decades with little or no government regulations, legitimate distance learning programs were viewed as "mail order" degrees and thus, looked down upon by brick and mortar schools as well as the business world. Schools often refused to accept transfer credits or admit holders of such degrees into their graduate programs. Employers, at least of top firms tended to reject such job applicants.
In more recent years however, many top tier universities have been offering on-line degrees adding legitimacy. American institutions of higher learning are slow to adapt new methodologies but are beginning to recognize we have already passed through the "Information Age."
So Daveel, I would say that if you earn your degree from a top tier university and your diploma does not make note that the degree is from the school's on-line division, your degree will increase its likelihood of being accepted in both the academic and business worlds. This is especially true of earned degrees in areas that are a natural match for on-line study, namely anything that has to do with computers.
Daveel, I suggest that you do an internet search on the history of distance learning. You will better understand the negative views that were held in the not so distant past. I would also highly suggest that you discuss the validity of such a degree with people in position to make such judgments. This specifically means academics people who hire professors in universities and human resource managers who are responsible for hiring in your intended field. If your degree is intended to be used for licensing purposes, contact the government agency that sets the licensing requirements. They will be the ones who can best answer your question.
Best wishes to you Daveel.