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Is it legal to publish an Open Access article at MDPI and then reupload this article after publication at researchgate? Furthermore, is it possible to change the layout of the article into a standard 2-column article for the upload at researchgate? I am asking because I do not know if there are any legal issues with this.

I am not very happy with the layout of articles at mdpi, but I didnt came across a different publisher, that is that fast, which is the reason I choose mdpi.

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Yes, you have the right to do this under the Creative Commons CC BY 4.0 license that MDPI uses as standard, as long as you link back to the original version and give credit to authors and publisher. You retain copyright as an author.

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