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I recently graduated from a master's degree while working on an interesting but niche intersection of machine learning and biology. This area is of my personal interest and I believe it can impact the world in the future but it is not readily marketable. Therefore, I decided to choose a position in a tech company as a software engineer, with works and responsibilities that are unrelated to this niche area. I don't want to give up my efforts in my previous research area and want to continue doing research as a personal passion in my free time such weekends or when I come home from my daily work (which btw I enjoy very much). I find this idea particularly interesting as I would have more freedom to think freely without feeling the pressure of publish or perish and I think it would make the research even more enjoyable to me compared to when I was in grad school and under pressure. However, there might be potential issues and caveats that I am blindsided to them, so I wanted to ask the people here about the potential downsides or considerations in doing research as a part-time or second career.

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The main issue I can think is time. Other people who will be working on the same research field will spend their full working week on the topic while you will be working only in your free time (weekends etc.). So you will be progressing very slowly and there is a high chance that you might get scooped if you are working on some hot research topic.

All that assuming that you have some average productivity aptitude and you are not some productivity beast that is able to finish up work in 1/10th of time than the rest :)

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    Yeah, I understand the time limit that you mentioned. I am not afraid of being scooped as this field is not that popular and mainstream in general. However, allocating enough time to provide relevant and timely results is a concern as you mentioned. – CoderInNetwork Jun 27 '20 at 5:48
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Also, even if your daytime work is not related to your personal research, you may either have signed something about IP (=intellectual property), so that your employer feels that they own essentially everything you do that is even remotely related to your job. I'd think you should look into this, discreetly...

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    Yes, be careful what you sign; but be even more careful if the employment contract you sign doesn't explicitly mention IP, because in that case, local public law will define a default position for who owns any IP you create, and that default position may surprise you. – Daniel Hatton Sep 19 '20 at 19:43
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In addition to time constraints, you'll want to try to collaborate with people or professors from your institution. It is pretty difficult to do good work alone, especially in computational fields. One benefit of doing research on your own time is the flexibility to explore areas that may not have immediate funding or interest, but could be impactful.

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