Me and my supervisor were written a paper on medical imaging as a part of my master thesis, we sent a paper to a journal for publishing, after a period of time the journal send us back the paper with some comments from each reviewer. In our perspective a number of questions from reviewers comes from a word "Novel" that we wrongly put it in a title. And I want to ask you professionals that is it possible to change the title? is it a good or bad idea? this will make our paper to be refused by reviewers or not?
I would say yes it's possible as I have just had a paper accepted where I changed the title during review. Now the change wasn't huge and the referee had commented on the title (and I'm not submitting to medical journals). Like most things in a refering process, if you can justify it and the referee(s) accept the change you can get away with alot. It might get more complicated if you posted the paper on a preprint server beforehand (only in the sense people might mistake it as two papers, depending on the level of "change")