I recently received the reviewer comments for the work submitted to a decent journal. In the comments, the reviewers advised me to revise the manuscript. The editor noted that "If you are prepared to undertake the work required, I would be pleased to reconsider my decision."
One of the three reviewers commented that a stronger experimental validation is required before the paper could be considered for publication. My thesis is only related to modeling of an experimental process and the requested experiments cannot be carried out at this stage. I have validated my simulation results with published experiments, so I am not sure why the reviewer has asked me to do experiments.
Other two reviewers have given major revisions pertaining to my modeling which I can confidently respond through some additional simulations.
My question is that if I don't carry out the work asked by the first reviewer and address the comments of the other two, will my paper be rejected for not addressing all the reviewers? In that case, is it even worth pursuing?