We submited a manuscript to an Elsevier journal eight months ago – we basically got a clear straight-forward rejection:

Although the reviewers commented favourably on your manuscript, there were significant criticisms that preclude publications. These comments indicated that your manuscript has some serious weakness. We would be willing to reconsider the manuscript after it has undergone a major revision that takes into account the criticisms of the reviewers, with no assurance of acceptance

We spent about seven months, performing more experiments and answering all concerns raised and we resubmitted. We thought we received a conditional acceptance. Two reviewers replied that we addressed all their concerns, third reviewer however commented that the work cannot be possible (simply based on his/her belief) and went on to ask a few things that is not really relevant and suggested that we discuss a big bunch of stuff unrelated to our study in the discussion (i.e., add a lot of speculations).

The reviewers commented favorably on your manuscript, but had some worthwhile suggestions. I am pleased to accept your manuscript, based on your revising it according to the recommendations of the reviewers"

So we followed the third reviewer’s suggestions and amended accordingly. We did a couple more experiments, all supporting that our initital conclusions were correct. Then 2.5 weeks later, we got a rejection:

I regret to relate that your manuscript cannot be accepted for publications. In addition to the comments of the outside reviewer’s, the editors have considered whether merely editorial or technical corrections would result in a priority score sufficient for acceptance, by comparison to other manuscripts we currently receive.

No new reviewer comments were included. Prior to sending us the decision, the editor did contact us about declaring whether a western blot was cropped.

We were expecting that the journal would accept it, as it stated: “I am pleased to accept your MS”. I felt like that we received a conditional acceptance but now a rejection. So did I get a rejection because our western blot is cropped? If they really don’t like that, we can always re-run the gel and present non-cropped images (these images are not presented in the manuscript, but on the response to reviewers only). Is this the reason why our manuscript was rejected?

It is worthwhile to appeal? Or would I be wasting time? If we didn’t receive a high priority score, why did they indicated conditional acceptance in the second decision letter?

I would really like to hear some honest opinions, cause my own ones are likely to be biased influenced by my frustration and disappointment.

  • 3
    Before submitting a formal appeal, you could contact the editor with a question instead: Based on the earlier conditional acceptance of your paper (include a quotation with the specific wording), how is a rejection possible after you have implemented all recommendations? If the editor notices that he made a mistake, he might be motivated to fix it. Commented Dec 7, 2017 at 11:16

1 Answer 1


I believe you have misunderstood what the first "acceptance" meant (which could have been worded better to prevent this).

A journal generally has many editors and an editorial board.

The typical journal review structure has your paper go to a single editor, who decides if the paper passes first muster and assigns reviewers if so. Once the review process is complete, that editor then decides if the paper is to be rejected, revised, or advanced to the full editorial board. Your "conditional acceptance" seems to be the first editor advancing the paper to the full editorial board. The board then made the final decision to reject the paper. Note that some journals (in some fields) can have a high rejection rate from the editorial board. So while that initial "acceptance" can feel like a victory you're not actually out of the woods yet.

I expect your chances for a successful appeal to be small. The decision seems only slightly based on your paper and mostly on the technical details of how the journal selects publications. They're unlikely to bend those to your benefit.

  • Thank you for your comment. Appreciate the feedback. The editor-in-chief did email me that morning "In reviewing xxxx, it has been noted that figure S2 has been cropped. Please note the cropping with line drawn on the figure and indicate in the legend that the line indicates that the figure was cropped. Please resubmit the paper with this change." - we simply just declared that we cropped the images.
    – skyrabbit
    Commented Dec 7, 2017 at 10:10
  • Tests samples were run in Well 1 and 2 and positive controls happened to be in well 8. So we combined the lanes digitally. We didn't thought this was a problem, because the purpose of these experiments show that the points raised by the 3rd reviewer is not accurate (as it is negative results and will not appear in the final MS). ------ so it bugs me a lot and can't stop to wonder, if we did the gel all in parallel, would our MS get accepted.
    – skyrabbit
    Commented Dec 7, 2017 at 10:13
  • If an Associate Editor gave us conditional acceptance. Why would the full editorial board reject us?
    – skyrabbit
    Commented Dec 7, 2017 at 10:15
  • 1
    I think this answer depicts the situation correctly, but it should put more blame on the editor for communicating the preliminary decision so badly. The word "acceptance" should never be used if the paper can still be rejected by the editorial board. Commented Dec 7, 2017 at 10:36
  • so i guess from the above comments, its not worthy to send an appeal : (
    – skyrabbit
    Commented Dec 7, 2017 at 10:45

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