Simply have them leave the class, they cannot disrupt if they are not there and a very strong message is sent to the others that it will not be tolerated. Repeat interruptions simply drop them from the class. I taught ordinanceordnance disposal and never tolerated for 1 instant a source of disruption. I would show them a photo of someone who needed to be fed, wiped, placed into bed, bathed for life. They were not even able to kill themselves and were a burden to everyone they loved for the rest of their life. Just have them leave, the remaining students will thank you for it and you can fulfil your goal of imparting knowledge instead of playing class cop.