I am new to my field (cell biology / immunology) and I would like to ask about the best practice to annotate or summarize research articles and reviews for long-term retrieval. When I start reading into a new topic, I end up highlighting almost each paragraph of the paper/review. This doesn't make any sense, and it is actually making me slow and frustrated and it is holding me from reading more. Could you please share your thoughts.
Update: although two very important points of how to approach new papers and how to tag them have been addressed in the answers so far, my main concern was about the new acquired details which I can't remember a few months later. For example, I read a paper about JAK/STAT signaling two months ago, now I can't remember for example which JAK attaches to which cytokine receptor and interacts with which STAT. I need to skim through the paper again to find this piece of information. So, what I am looking for is an approach to accumulate the new knowledge and to facilitate reviewing them without the need to skim through the paper again and again. I know this will come with experience, but at the beginning there are too many new facts to keep track of.